Effects of Solanum lycopersicum Fruit Extract on Cyclophosphamide-induced chromosome aberrations in mouse bone marrow cells

In the present study, the clastogenic effect of Solanum lycopersicum fruit extract has been evaluated against cyclophosphamide (CP)-induced chromosomal aberrations in the bone marrow cells of the mice. Single i.p. administration of Solanum lycopersicum fruit extract at different test doses, namely 500, 1000 and 1000 mg/kg body weight have provided protection, when given 24 hr prior to the single i. p. administration of cyclophosphamide (50 mg/kg body weight). A dose dependent inhibition of chromosomal aberrations was observed which was statistically significant (p<0.05) as compared to the cyclophosphamide group. It’s seems to have a preventive potential against CP-induced chromosomal aberrations in the bone marrow cells of the mice. Therefore, the results suggest a genotoxic potential of Solanum lycopersicum fruit extract.